Neuroimaging biomarkers in Alzheimer's disease and other dementias.
Identifieur interne : 001A54 ( Main/Exploration ); précédent : 001A53; suivant : 001A55Neuroimaging biomarkers in Alzheimer's disease and other dementias.
Auteurs : Victor L. Villemagne [France] ; Gaël Chételat [France]Source :
- Ageing research reviews [ 1872-9649 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Démence (), Démence (imagerie diagnostique), Démence (métabolisme), Humains, Maladie d'Alzheimer (), Maladie d'Alzheimer (imagerie diagnostique), Maladie d'Alzheimer (métabolisme), Marqueurs biologiques, Neuroimagerie (), Peptides bêta-amyloïdes (analyse), Peptides bêta-amyloïdes (métabolisme).
- MESH :
- analyse : Peptides bêta-amyloïdes.
- imagerie diagnostique : Démence, Maladie d'Alzheimer.
- métabolisme : Démence, Maladie d'Alzheimer, Peptides bêta-amyloïdes.
- Animaux, Démence, Humains, Maladie d'Alzheimer, Marqueurs biologiques, Neuroimagerie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Amyloid beta-Peptides.
- diagnostic imaging : Alzheimer Disease, Dementia.
- metabolism : Alzheimer Disease, Amyloid beta-Peptides, Dementia.
- methods : Neuroimaging.
- therapy : Alzheimer Disease, Dementia.
- Animals, Biomarkers, Humans.
Abstract
In vivo imaging of β-amyloid (Aβ) has transformed the assessment of Aβ pathology and its changes over time, extending our insight into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain. This knowledge is essential for therapeutic trial recruitment and for the evaluation of anti-Aβ treatments. Although cross sectional evaluation of Aβ burden does not strongly correlate with cognitive impairment, it does correlate with cognitive (especially memory) decline and with a higher risk for conversion to AD in the aging population and MCI subjects. This suggests that Aβ deposition is a protracted pathological process starting well before the onset of symptoms. Longitudinal observations, coupled with different disease-specific biomarkers to assess potential downstream effects of Aβ are required to confirm this hypothesis and further elucidate the role of Aβ deposition in the course of Alzheimer's disease.
DOI: 10.1016/j.arr.2016.01.004
PubMed: 26827785
Affiliations:
- France
- Basse-Normandie, Victoria (État)
- Caen, Melbourne
- Université de Caen Basse-Normandie, Université de Melbourne
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001A03
- to stream PubMed, to step Curation: 001979
- to stream PubMed, to step Checkpoint: 001979
- to stream Ncbi, to step Merge: 003071
- to stream Ncbi, to step Curation: 003071
- to stream Ncbi, to step Checkpoint: 003071
- to stream Main, to step Merge: 001A50
- to stream Main, to step Curation: 001A54
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Neuroimaging biomarkers in Alzheimer's disease and other dementias.</title><author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Victoria 3084, Australia; Department of Medicine, University of Melbourne, Austin Health, Victoria 3084, Australia; The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France. Electronic address: victorlv@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Victoria 3084, Australia; Department of Medicine, University of Melbourne, Austin Health, Victoria 3084, Australia; The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen</wicri:regionArea><wicri:noRegion>1077 Caen</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name><affiliation wicri:level="4"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France; Université de Caen Basse-Normandie, Unité Mixte de Recherche (UMR), S1077 Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, 14000 Caen, France; Unité 1077, Centre Hospitalier Universitaire de Caen, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France; Université de Caen Basse-Normandie, Unité Mixte de Recherche (UMR), S1077 Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, 14000 Caen, France; Unité 1077, Centre Hospitalier Universitaire de Caen, 14000 Caen</wicri:regionArea><wicri:noRegion>14000 Caen</wicri:noRegion><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26827785</idno><idno type="pmid">26827785</idno><idno type="doi">10.1016/j.arr.2016.01.004</idno><idno type="wicri:Area/PubMed/Corpus">001A03</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A03</idno><idno type="wicri:Area/PubMed/Curation">001979</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001979</idno><idno type="wicri:Area/PubMed/Checkpoint">001979</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001979</idno><idno type="wicri:Area/Ncbi/Merge">003071</idno><idno type="wicri:Area/Ncbi/Curation">003071</idno><idno type="wicri:Area/Ncbi/Checkpoint">003071</idno><idno type="wicri:Area/Main/Merge">001A50</idno><idno type="wicri:Area/Main/Curation">001A54</idno><idno type="wicri:Area/Main/Exploration">001A54</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neuroimaging biomarkers in Alzheimer's disease and other dementias.</title><author><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name><affiliation wicri:level="4"><nlm:affiliation>Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Victoria 3084, Australia; Department of Medicine, University of Melbourne, Austin Health, Victoria 3084, Australia; The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France. Electronic address: victorlv@unimelb.edu.au.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Molecular Imaging & Therapy, Centre for PET, Austin Health, Victoria 3084, Australia; Department of Medicine, University of Melbourne, Austin Health, Victoria 3084, Australia; The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen</wicri:regionArea><wicri:noRegion>1077 Caen</wicri:noRegion><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name><affiliation wicri:level="4"><nlm:affiliation>The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France; Université de Caen Basse-Normandie, Unité Mixte de Recherche (UMR), S1077 Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, 14000 Caen, France; Unité 1077, Centre Hospitalier Universitaire de Caen, 14000 Caen, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>The Florey Institute of Neuroscience and Mental Health, Victoria 3052, Australia; Institut National de la Santé et de la Recherche Médicale (Inserm), Unité, 1077 Caen, France; Université de Caen Basse-Normandie, Unité Mixte de Recherche (UMR), S1077 Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, 14000 Caen, France; Unité 1077, Centre Hospitalier Universitaire de Caen, 14000 Caen</wicri:regionArea><wicri:noRegion>14000 Caen</wicri:noRegion><orgName type="university">Université de Caen Basse-Normandie</orgName><placeName><settlement type="city">Caen</settlement><region type="region" nuts="2">Basse-Normandie</region></placeName></affiliation></author></analytic><series><title level="j">Ageing research reviews</title><idno type="eISSN">1872-9649</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer Disease (diagnostic imaging)</term><term>Alzheimer Disease (metabolism)</term><term>Alzheimer Disease (therapy)</term><term>Amyloid beta-Peptides (analysis)</term><term>Amyloid beta-Peptides (metabolism)</term><term>Animals</term><term>Biomarkers</term><term>Dementia (diagnostic imaging)</term><term>Dementia (metabolism)</term><term>Dementia (therapy)</term><term>Humans</term><term>Neuroimaging (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Démence ()</term><term>Démence (imagerie diagnostique)</term><term>Démence (métabolisme)</term><term>Humains</term><term>Maladie d'Alzheimer ()</term><term>Maladie d'Alzheimer (imagerie diagnostique)</term><term>Maladie d'Alzheimer (métabolisme)</term><term>Marqueurs biologiques</term><term>Neuroimagerie ()</term><term>Peptides bêta-amyloïdes (analyse)</term><term>Peptides bêta-amyloïdes (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Amyloid beta-Peptides</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Peptides bêta-amyloïdes</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Démence</term><term>Maladie d'Alzheimer</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Alzheimer Disease</term><term>Amyloid beta-Peptides</term><term>Dementia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Neuroimaging</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Démence</term><term>Maladie d'Alzheimer</term><term>Peptides bêta-amyloïdes</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Alzheimer Disease</term><term>Dementia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Biomarkers</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Démence</term><term>Humains</term><term>Maladie d'Alzheimer</term><term>Marqueurs biologiques</term><term>Neuroimagerie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vivo imaging of β-amyloid (Aβ) has transformed the assessment of Aβ pathology and its changes over time, extending our insight into Aβ deposition in the brain by providing highly accurate, reliable, and reproducible quantitative statements of regional or global Aβ burden in the brain. This knowledge is essential for therapeutic trial recruitment and for the evaluation of anti-Aβ treatments. Although cross sectional evaluation of Aβ burden does not strongly correlate with cognitive impairment, it does correlate with cognitive (especially memory) decline and with a higher risk for conversion to AD in the aging population and MCI subjects. This suggests that Aβ deposition is a protracted pathological process starting well before the onset of symptoms. Longitudinal observations, coupled with different disease-specific biomarkers to assess potential downstream effects of Aβ are required to confirm this hypothesis and further elucidate the role of Aβ deposition in the course of Alzheimer's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Basse-Normandie</li><li>Victoria (État)</li></region><settlement><li>Caen</li><li>Melbourne</li></settlement><orgName><li>Université de Caen Basse-Normandie</li><li>Université de Melbourne</li></orgName></list><tree><country name="France"><region name="Victoria (État)"><name sortKey="Villemagne, Victor L" sort="Villemagne, Victor L" uniqKey="Villemagne V" first="Victor L" last="Villemagne">Victor L. Villemagne</name></region><name sortKey="Chetelat, Gael" sort="Chetelat, Gael" uniqKey="Chetelat G" first="Gaël" last="Chételat">Gaël Chételat</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A54 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A54 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26827785
|texte= Neuroimaging biomarkers in Alzheimer's disease and other dementias.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26827785" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |